#Smart zipper lock zip#

Compared with the regular H 1/H 2 mixture, the DNA/RNA NFs produced a higher-contrast fluorescence signal. With the addition of a DNA-nuclear localization peptide component in the same NF, nuclear TR can also be sensitively detected. After NF internalization by the cells, the intracellular RNase H acts as the “key” to specifically open the DNA/RNA NFs by cleaving the RNA in the DNA/RNA hybrid, releasing high amounts of H 1 and H 2 in a confined space and thereby facilitating the HCR amplification analysis of cytoplasmic TR. The functional DNAs include the fluorescence molecular beacon H 1 for TR recognition, H 2 for hybrid chain reaction (HCR) and DNA-cholesterol for size control. First, a long RNA generated by rolling circle transcription acts as both the “smart zipper lock” and the delivery carrier to alternately lock multiple functional DNAs through DNA-RNA base pairing, and the resulting RNA/DNA hybrids self-assemble into packed NFs. Here, we designed a facile DNA/RNA nanoflower (NF) to perform the controlled loading of multiple probes and rapid intracellular release based on the “zipper lock-and-key” strategy.

While novel nanomaterials enhance delivery efficiency, uncontrolled loading and slow intracellular release remain major challenges for multiple-probe delivery. The efficient delivery of multiple nucleic acid probes to target cells is critical for nucleic acid-based methods to successfully image low-abundance TR in living cells.

#Smart zipper lock zip#

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